Medical research and services company Charles River Laboratories International Inc. said Friday it received a $111.6 million grant from the National Cancer Institute.

The 10-year contract doubles the size of the company's current contract with NCI. Charles River will use a portion of the funds to build a shared-use research and services facility. The facility is expected to be completed by the third quarter of 2008.

The company will also assume management responsibilities for NCI's and the National Institutes of Health Tumor and Natural Products Repositories in support of the Development Therapeutics Program. The repositories store tumor samples used by researchers studying causes of cancer and searching for treatments.

Charles River, which focuses on developing research models for the drug discovery industry, saw revenue totaling $1.12 billion in 2005.

The portion of the facility used by NCI will be staffed by Charles River's consulting and staffing services group.

Shares of Charles River fell 42 cents to $41.22 on the New York Stock Exchange in morning trading.